Medical Books

 

Screen Shot 2014-11-20 at 14.46.33The Dose-Response Relationship of Vitamin E and Lung Cancer Risk: Empirical and Mechanism-Based Models

Published 2013 by GRIN Publishing

Country of publication: Germany

IBSN (eBook): 978-3-656-50652-2

IBSN (Book): 978-3-656-50769-7

IBSN-10: 3656507694

IBSN-13: 978-3656507697

 

Language: English

Classification: Medicine – Neoplasms, Oncology

Pages: 88

Book Description

Lung cancer is considered one of the most common and fatal form of cancer and as such, it requires urgent attention from medical researchers in order to slow its current epidemic proportions. This book analyzes the dose-response relationship of vitamin E intake on the risk of developing lung cancer, with emphasis placed on both dietary and supplemental intakes of vitamin E, as well as the various barriers to identifying the biological processes that drive lung cancer formation. The aim of the book is to improve our understanding of the empirical and mechanism-based vitamin E-lung cancer models, and to aid in developing new strategies for the treatment and prevention of lung cancer. The book sets the stage for a discussion on the dose-response modeling of vitamin E intake and lung cancer risk by briefly describing the concept of dose-response and its quantified strength of association in two selected cohort studies, and by presenting the cellular mechanisms through which vitamin E may exert its anti-cancer activity. Safe and beneficial dietary and supplemental doses of vitamin E are estimated, as are its critical doses. Throughout the book, gaps in knowledge relating to the evaluation of the relationship between vitamin E intake and lung cancer risk, especially those in dose-response analyses, are revealed. Understanding these gaps and their implications can inform the design of new dose-response studies, which may add to our knowledge of vitamin E activity and shed light on issues related to its bioavailability and action in lung cells. The book concludes by summarizing the main conclusions and implications derived from this assessment.

Citation

Please cite this publication as:

Akrawi, W. (2013). The dose-response relationship of vitamin E and lung cancer risk: Empirical and mechanism-based models. Germany: GRIN Publishing.

 

 

Screen Shot 2014-11-20 at 14.31.40Statistical Evaluation of Two Medical Databases: A Framework for Descriptive, Bivariate, and Multivariate Analyses

Published 2013 by GRIN Publishing

Country of publication: Germany

IBSN (eBook): 978-3-656-50650-8

IBSN (Book): 978-3-656-50688-1

IBSN-10: 3656506884

IBSN-13: 978-3656506881

 

Language: English

Classification: Medicine – Medical Frontiers and Special Areas

Pages: 136

Book Description

Although statistics is not always a popular subject, perhaps because it relies heavily upon mathematics, statistical skills are necessary to anyone intending to practice medicine or engage in health-related research or in medical care service delivery. Covering every step of some of the most commonly used data analysis techniques, this book offers a road map and strategies to adopt when medical students, doctors, or other health professionals face challenges in handling and analyzing clinical or survey data – from preliminary evaluations of the databases in question to how to effectively interpret the results.

The book is divided into two sections, each is packed with distinct perspective on the database assessed, taking the reader through the process of developing answerable and relevant research questions and their corresponding hypotheses. Using SPSS, chapters 1-5 analyze data derived from a noise-testing scores database by presenting descriptive statistics and statistical hypothesis testing, including potential templates for presenting overviews of the study designs, guidance on how to choose appropriate tests, ways to understand their assumptions, guidelines on how to correctly check them, and which limitations are important to consider. In chapters 6-9, another set of statistical analyses are carried out utilizing data derived from the Ugandan database, which provides records of the perception of chances of getting AIDS among Ugandan women. The effects of region, place of residence, and condom-use on ages at first marriage and intercourse are investigated thoroughly. General conclusions and observations are recorded in the final chapter.

Addressing most, if not all, aspects of ANOVAs, ANCOVAs, MANOVAs, MANCOVAs, Chi-square tests, and t-tests, this book is designed as a toolkit with much-needed directions to aid those who have to enter the world of medical statistics.

Citation

Please cite this publication as:

Akrawi, W. (2013). Statistical evaluation of two medical databases: A framework for descriptive, bivariate, and multivariate analyses. Germany: GRIN Publishing.

Intended Audience

  • Professional and scholarly (e.g., doctors with interest in statistics, educators, researchers);
  • College or higher education (e.g., master’s and PhD students); and
  • General (e.g., anyone interested in hands-on experience on data analysis techniques using SPSS).

 

 

Screen Shot 2014-11-20 at 14.13.47 copyMaster’s Thesis I: Function-Analysis of Seventeen Function-Unknown Genes in Bacillus Subtilis

Published 2013 by GRIN Publishing

Country of publication: Originally, Denmark; by GRIN, Germany

IBSN (eBook): 978-3-656-46782-3

IBSN (Book): 978-3-656-46902-5

IBSN-10: 3656469024

IBSN-13: 978-3656469025

Language: Danish

Pages: 159

Summary

This research was part of the European Union-funded Bacillus Subtilis Genome Sequencing Project. In this book, the function and biological roles of 17 newly sequenced genes were analyzed by selectively and specifically generating more than 40 bacterial strains with mutations in the 17 function-unknown genes.

Citation

Please cite this publication as:

Akrawi, W. (1998). Master’s Thesis I: Function-Analysis of Seventeen Function-Unknown Genes in Bacillus Subtilis (Master’s thesis I). Germany: GRIN Publishing.

 

 

Screen Shot 2014-11-20 at 14.22.56A Comprehensive Assessment of Biological Function of Newly Sequenced yutK Gene in Basillus Subtilis

Published 2013 by GRIN Publishing

Country of publication: Originally, Denmark; by GRIN, Germany

IBSN (eBook): 978-3-656-47467-8

IBSN (Book): 978-3-656-47477-7

IBSN-10: 365647477X

IBSN-13: 978-3656474777

 

Language: Danish

Pages: 152

Summary

This research was also part of the Bacillus Subtilis Genome Sequencing Project. In Master’s Thesis II, the physiological function of the newly sequenced yutK gene in Bacillus subtilis was analyzed through the examination of the gene expression profiles of 4 genetically modified strains and comparing their growth rates with that of the wild type, enabling an assessment of the essentiality of this gene for cell integrity, growth and survival.

Citation

Please cite this publication as:

Akrawi, W. (1999). A Comprehensive Assessment of Biological Function of Newly Sequenced yutK Gene in Basillus Subtilis (Master’s thesis II). Germany: GRIN Publishing.

 

 

Cover-dissertation-insideThe Association Between Vitamin E Intake and Lung Cancer Risk and the Effect Modification of Dietary Intake of Fat and Fatty Acids on This Association: A Case-Control Study Based on the NHANES Datasets 1999-2010.

Published 2013 by ProQuest/UMI

Country of publication: United States of America

IBSN: 9781303351792

Language: English

Classification: Medicine, Oncology, Epidemiology, Public Health, Nutrition

References: 426

Pages: 323

Book Description

The relationship between vitamin E intake and lung cancer risk has been examined in several studies; however, the evidence is limited or inconclusive. In this study, this association was examined using data from the 1999-2010 National Health and Nutrition Examination Survey, which provides information on the health and nutritional status of a nationally representative sample of Americans. To the investigator’s knowledge, this is the first population-based study that examines the effects of both dietary and supplemental intakes of vitamin E on lung cancer risk while evaluating individually dietary intakes of total fat, mono- or polyunsaturated fatty acids as potential effect modifiers.

Respondents diagnosed with lung cancer and those without any serious medical conditions were screened as cases and controls, respectively. The ratio of cases to controls was 1:4. Using year groups as the stratification variable, a proportionate stratified random sample of 365 subjects (73 cases and 292 controls) was selected, with all cases included. Multiple imputation was used to handle missing data, and logistic regression was conducted to estimate odds ratios and 95% confidence intervals.

Overall, the findings showed that total vitamin E intake was inversely associated with lung cancer risk (adjusted OR = 0.237, 95% CI [0.085-0.666]), indicating that individuals who consumed adequate levels of vitamin E (≥15mg α-tocopherol equivalents per day) were 76.3% less likely to develop lung cancer than those who consumed inadequate (<15mg) levels of vitamin E. However, the interaction between vitamin E intake and dietary intake of polyunsaturated fatty acids was positively associated with lung cancer risk, increasing the risk by nearly fivefold (adjusted OR = 4.886, 95% CI [1.113-21.453]), and changing the odds ratio observed between vitamin E intake and lung cancer risk (adjusted OR = 0.020, 95% CI [0.001-0.278]) by more than 90%.

These results suggest that consuming adequate/beneficial levels of vitamin E and avoiding too much polyunsaturated fatty acids intake, coupled with smoking cessation or lifelong abstinence from smoking, may be essential to reduce lung cancer risk and to improve long-term health and wellbeing. Given the limitations inherent in this form of analysis, the findings need to be confirmed in further studies.

Citation

Please cite this publication as:

Akrawi, W. (2013). The Association Between Vitamin E Intake and Lung Cancer Risk and the Effect Modification of Dietary Intake of Fat and Fatty Acids on This Association: A Case-Control Study Based on the NHANES Datasets 1999-2010 (Doctoral dissertation). Available through ProQuest Dissertations and Theses database.

 

 

PLEASE NOTE: Any revenues that may generate from the sales of Dr. Akrawi’s publications are completely donated to charity.